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CATEGORIES:Conferences/Seminars/Lectures
DESCRIPTION:This seminar is being held virtually. Please click here to atte
 nd. \n\nCross-modal plasticity in adults\n\nHey-Kyoung Lee. PhD\n\nJohns Ho
 pkins University\n\nCross-modal plasticity refers to the adaptation of the 
 brain after losing a sensory modality\, which enables the organism to navig
 ate the world with the remaining senses. One such example seen in blind sub
 jects is the activation of the visual cortex by Braille or speech. Such cro
 ss-modal recruitment is thought to be beneficial as it allows the spared se
 nsory information to be processed by a larger cortical area. In addition\, 
 there is enhancement and refinement of the remaining senses via compensator
 y plasticity of the spared sensory cortices. We found that a short duration
  of vision loss triggers large-scale circuit plasticity across the primary 
 sensory cortices even in adults. Such cross-modal plasticity is robust and 
 manifests differently in the deprived visual cortex (V1) and the spared aud
 itory cortex (A1). Plasticity in V1 mainly involves potentiation of intraco
 rtical excitatory synapses\, while in A1 it manifests as potentiation of th
 e feedforward pathways at the expense of intracortical inputs. Mechanistica
 lly\, plasticity observed in both V1 and A1 conforms to Hebbian plasticity 
 coupled to the “sliding threshold” metaplasticity. I will discuss the funct
 ional consequences of the circuit level cortical plasticity\, and present d
 ata that cross-modal plasticity is observed even earlier in the sensory pro
 cessing at the level of thalamic gating.\n\nDr. Hey-Kyoung Lee received her
  B.S. degree in biology from Yonsei University (Seoul\, Korea) in 1992. In 
 1997\, she completed her graduate studies under the mentorship of Dr. Mark 
 Bear\, and received a Ph.D. in neuroscience from Brown University (Providen
 ce\, Rhode Island). Her thesis work focused on the cellular and molecular m
 echanisms of bidirectional synaptic plasticity. Dr. Lee pursued her postdoc
 toral training in neuroscience with Dr. Rick Huganir at the Johns Hopkins S
 chool of Medicine (Baltimore\, Maryland)\, where she studied the role of AM
 PA receptor phosphorylation in synaptic plasticity. In 2003\, Dr. Lee joine
 d the University of Maryland (College Park\, Maryland) as an Assistant Prof
 essor of Biology. She was awarded the Alfred Sloan Fellowship in 2004 and w
 as nominated as one of the “Yonsei 100 Women Leaders” in 2006. In 2009\, sh
 e was awarded the Junior Faculty Award from the College of Chemical and Lif
 e Sciences\, received tenure from the University of Maryland\, and promoted
  to an Associate Professor. In 2011\, Dr. Lee joined the Department of Neur
 oscience at Johns Hopkins University as an Associate Professor. In 2016\, D
 r. Lee received tenure and was promoted to a Full Professor. She is current
 ly serving as the Chair of Undergraduate Neuroscience Program at Johns Hopk
 ins University.
DTEND:20210930T210000Z
DTSTAMP:20260314T091829Z
DTSTART:20210930T200000Z
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SEQUENCE:0
SUMMARY:Colloquium on the Brain and Cognition with Hey-Kyoung Lee\, PhD\, J
 ohns Hopkins University
UID:tag:localist.com\,2008:EventInstance_37651097468887
URL:https://calendar.mit.edu/event/colloquium_on_the_brain_and_cognition_wi
 th_hey-kyoung_lee_phd_johns_hopkins_university
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