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VERSION:2.0
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CALSCALE:GREGORIAN
X-WR-CALNAME:Bioinformatics Seminar
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260616T124030Z
UID:tag:localist.com\,2008:EventInstance_50834342775200
DTSTART:20251029T153000Z
DTEND:20251029T163000Z
DESCRIPTION:Speaker: Elinor Karlsson (University of Massachusetts Medical S
 chool / Broad Institute)\n\nTitle:  Exploring 100 million years of mammali
 an evolution for the origins\nof exceptional traits\n\nAbstract: The Zoono
 mia Project\, one of the largest comparative genomics initiatives ever un-
 \ndertaken\, compared 240 mammalian species spanning over 100 million year
 s of evo-\nlutionary history. This work revealed that at least 11% of the 
 human genome is evo-\nlutionarily constrained\, and that these constrained
  bases are more enriched for vari-\nants explaining common disease heritab
 ility than any other functional annotation.\nYet nearly half of the most h
 ighly constrained bases remain unannotated in exist-\ning datasets\, under
 scoring how much of the genome’s regulatory landscape remains\nunexplore
 d. Building on this foundation\, we are integrating the “common garden
 ”\nframework from classical ecology with modern genomics to assay and co
 mpare cel-\nlular responses across diverse mammals. This effort includes R
 NA-seq and ATAC-\nseq profiling across 12 species and seven experimental s
 tates varying in temperature\,\noxygen\, and glucose levels. We can identi
 fy molecular responses shared across mam-\nmals and those unique to specie
 s with remarkable physiological adaptations—such\nas camels that thrive 
 in extreme heat\, seals that dive deeply without suffering oxygen\ndamage\
 , and bats that tolerate extreme blood sugar fluctuations. Uncovering the 
 ge-\nnomic mechanisms that enable these exceptional traits may reveal new 
 strategies for\nimproving human health.\n\nIn person or on Zoom at https:/
 /mit.zoom.us/j/93513735220
GEO:42.361965;-71.090261
LOCATION:Building 32\, G575
SUMMARY:Bioinformatics Seminar
URL;VALUE=URI:https://calendar.mit.edu/event/copy-of-bioinformatics-seminar
 -9621
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