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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:NeuroLunch: Zeguan Wang (Boyden Lab) & Liu Yang (Choi Lab)
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261006T210904Z
UID:tag:localist.com\,2008:EventInstance_50762349822867
DTSTART:20251027T160000Z
DTEND:20251027T170000Z
DESCRIPTION:Speaker:  Zeguan Wang (Boyden Lab) \n\nTitle: Towards whole-bra
 in\, cellular-resolution imaging and manipulation of neural voltage in lar
 val zebrafish\n\nAbstract: Recording the neural voltage activity of an ent
 ire vertebrate brain at cellular and millisecond resolution will have a tr
 ansformative impact on systems neuroscience. Despite progress in fluoresce
 nt voltage indicators\, existing optical methods remain limited in speed\,
  resolution\, field of view\, or signal quality to meet this challenge. We
  addressed the challenge by developing a novel remote-scanning light-sheet
  microscope\, that enables imaging the neural voltage of neurons distribut
 ed throughout the entire larval zebrafish brain at 200 Hz. We observed tha
 t neurons firing at different times during a milliseconds-scale sequence w
 ere located at different brain locations\, for sequences elicited by a vis
 ual stimulus\, which mapped onto locations throughout the optic tectum\, a
 s well as during stimulus-independent bursts\, which mapped onto locations
  in the cerebellum and medulla. Next\, we will improve the microscope to c
 apture >80% of all neurons\, and pair it with two-photon holographic optog
 enetics to enable simultaneous imaging and manipulation of neural voltage 
 across the entire brain. We will then apply the new platform to study neur
 al mechanisms underlying learning in larval zebrafish.\n\n \n\n \n\nSpeake
 r: Liu Yang (Choi Lab)\n\nTitle: IL-1R-positive dorsal raphe neurons drive
  self-imposed social withdrawal in sickness\n\nAbstract: Sick animals exhi
 bit behavioral changes that extend beyond physiological symptoms\, such as
  appetite loss and hypoactivity\, and include a decline in social interact
 ions. While social isolation during sickness has been recognized to have t
 he evolutionary benefits of staving off disease spread\, the molecular and
  neural mechanisms underlying this response remain unclear. Cytokines—im
 mune-derived signaling molecules—have emerged as neuromodulators impacti
 ng brain function during inflammation. Through behavioral screening\, we i
 dentified a unique role for the cytokine interleukin-1β (IL-1β) in promo
 ting social withdrawal during sickness. IL-1β directly modulates the acti
 vity of IL-1R1-expressing neurons in the dorsal raphe nucleus (DRN) (IL-1R
 1DRN). Activation of these neurons is sufficient to elicit social withdraw
 al\, while their inhibition or genetic deletion of IL-1R1 rescues self-imp
 osed social isolation during systemic inflammation. Our findings reveal a 
 neural mechanism that actively promotes social disengagement in sick anima
 ls\, highlighting the role of IL-1R1DRN neurons in driving these behaviora
 l adaptations.
GEO:42.362302;-71.091766
LOCATION:Building 46\, 3310
SUMMARY:NeuroLunch: Zeguan Wang (Boyden Lab) & Liu Yang (Choi Lab)
URL;VALUE=URI:https://calendar.mit.edu/event/copy-of-neurolunch-danai-georg
 ia-sakelliadou-miller-lab-cyn-fang-kanwisher-lab
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