Phillip A. Sharp Lecture in Neural Circuits
Tuesday, May 28, 2019 at 4:00pm to 5:00pm
Building 46, Singleton Auditorium, 46-3002
43 VASSAR ST, Cambridge, MA 02139
Yang Dan, PhD; HHMI, UC Berkeley
Title: A motor theory of sleep-wake control
Abstract: Sleep is a fundamental biological process, and its disruption has profound impacts on human health. Using a variety of techniques including optogenetics, electrophysiology, imaging, and gene expression profiling, we identify key neurons in the sleep control circuits and map their synaptic connections. Sleep appears to be controlled by a highly distributed network spanning the forebrain, midbrain, and hindbrain, where REM and non-REM sleep neurons are part of the central somatic and autonomic motor circuits. The intimate association between the sleep and autonomic/somatic motor control circuits suggests that a primary function of sleep is to suppress motor activity.