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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Physical Math Seminar
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261009T205424Z
UID:tag:localist.com\,2008:EventInstance_45032889507583
DTSTART:20231212T193000Z
DTEND:20231212T203000Z
DESCRIPTION:Speaker:  Allon Klein   (Harvard University)\n\nTitle:    Learn
 ing dynamics from single cell snapshorts: lessons from physics\n\nAbstract
 :  \n\nHigh-dimensional snapshots of populations in motion can reveal key 
 aspects of their underlying dynamics. In biology\, profiling of single cel
 l molecular states has been used to order events in cell differentiation\,
  cell cycle\, and perturbation response by methods that fit cell states to
  a curve or a tree. A more important goal still is to predict future behav
 ior from cell state\, in order to identify regulators of behavior. I will 
 discuss our work predict differentiation fates from single cell molecular 
 profiles\, using ideas from physics: (1) Fokker-Planck equations and their
  implementation on graph representations of single cell data\, (2) identif
 ying hidden information in dynamic processes\, and (3) detecting convergen
 t (non-tree-like) cellular dynamics through conformal symmetry violations 
 in lineage-tracing data. We apply these approach to bone marrow hematopoie
 sis.
GEO:42.358262;-71.090045
LOCATION:Building 2\, 449
SUMMARY:Physical Math Seminar
URL;VALUE=URI:https://calendar.mit.edu/event/physical_math_seminar_8520
CATEGORIES:Conferences/Seminars/Lectures
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