About this Event
Preclinical testing of implantable medical devices that function in dynamic environments is typically conducted in simplified in vitro models before moving to animal models. There is an unmet need for high fidelity physical testbeds to bridge the gap between these two preclinical models. In this talk I will discuss hybrid biorobotic matrices that are designed to recapitulate pulmonary and cardiac biomechanics in vitro. I will describe how we exploit advancements in soft actuator technology to build soft active anthropomorphic matrices that can replicate diaphragmatic and cardiac muscle to drive lung ventilation and hemodynamic circulation respectively. First, I will discuss how a soft robotic diaphragm is programmed to mimic clinical motion, and when integrated into a simulator with abdominal and thoracic chambers subjected to physiological pressures, can drive preserved ex vivo lung inflation and deflation. Next, I will describe a bioinspired soft robotic heart that preserves the anatomical intracardiac structures but is powered by synthetic, soft robotic myocardium (heart muscle) which will drive blood flow in an instrumented circulatory flow loop. Finally, I will discuss the integration of both systems into a modular simulator platform with dynamic, anthropomorphic heart, lungs and diaphragm. As an exemplary configuration of this technology, I will describe how we simulate the Fontan physiology - a surgically corrected pediatric cardiac condition that affects both the cardiovascular and respiratory systems. This organosynthetic simulator combines robotics with biological tissue for increased biofidelity and has vast utility in quantitative research and development, device testing and as a hands-on, interactive visualization platform for enhanced medical training and pedagogy.
Bio
Ellen Roche is the W.M Keck Foundation Career Development Assistant Professor at the Institute for Medical Engineering and Science and the Department of Mechanical Engineering at the Massachusetts Institute of Technology. She directs the Therapeutic Technology Design and Development Lab. She completed her PhD at Harvard University School of Engineering and Applied Sciences. Her research focuses on applying innovative technologies to the development of medical devices. Her research includes development of novel devices to repair or augment cardiac function using disruptive approaches such as soft robotics, combination of mechanical actuation with delivery of cell therapy, and use of light activated biodegradable adhesives. Prof. Roche was employed in the medical device industry for over five years as a research and development engineer and employs her understanding of the medical device industry and the regulatory pathways to medical device commercialization in her academic research. She holds 5 issued patents, with ten pending and is the authors of over 40 conference/journal papers. She is the recipient of multiple awards including the Fulbright International Science and Technology Award, the Wellcome Trust Seed Award in Science, an American Heart Association Pre-Doctoral Award, a National Science Foundation CAREER Award and a Charles H. Hood Award for Excellence in Child Health Research.
1 person is interested in this event
Please click the link below to join the webinar:
https://mit.zoom.us/j/98758742464
Or iPhone one-tap :
US: +16465588656,,98758742464# or +16699006833,,98758742464#
Or Telephone:
Dial(for higher quality, dial a number based on your current location):
US: +1 646 558 8656 or +1 669 900 6833
Colombia: +57 1 508 7702 or +57 2 620 7388
Mexico: +52 229 910 0061 or +52 554 161 4288
Estonia: +372 660 1699 or +372 880 1188
Peru: +51 1 707 5788 or +51 1 730 6777
Hong Kong, China: +852 5808 6088
Sweden: +46 8 4468 2488 or +46 850 539 728
Argentina: +54 343 414 5986 or +54 112 040 0447 or +54 341 512 2188
Italy: +39 020 066 7245 or +39 069 480 6488
Canada: +1 647 558 0588
Luxembourg: +352 2786 1188 or +352 2786 4277
Czechia: +420 2 2888 2388 or +420 5 3889 0161
Netherlands: +31 20 241 0288 or +31 20 794 0854
France: +33 7 5678 4048 or +33 1 7037 2246 or +33 1 7037 9729
Poland: +48 22 307 3488 or +48 22 398 7356
Slovakia: +421 233 056 888 or +421 233 418 515
Belgium: +32 2 290 9360 or +32 2 588 4188
Korea, Republic of: +82 2 6022 2322 or +82 2 6105 4111
Malta: +356 2776 1777 or +356 2778 1288
Dominican Republic: +1 829 947 9220 or +1 829 956 2188
Panama: +507 833 9588
Greece: +30 211 198 4488 or +30 231 118 0599
Romania: +40 31 630 1088 or +40 37 170 0418
Turkey: +90 216 900 1866 or +90 216 900 2606
Brazil: +55 11 4680 6788 or +55 21 3958 7888
Lithuania: +370 3799 9260 or +370 5214 1488
Cyprus: +357 2 200 0888 or +357 2 505 4777
Finland: +358 3 4109 2129 or +358 9 4245 1488
Hungary: +36 1 408 8456 or +36 1 701 0488
Slovenia: +386 1600 3102 or +386 1888 8788
Australia: +61 2 8015 6011 or +61 8 7150 1149
Japan: +81 3 4578 1488 or +81 524 564 439
Chile: +56 23 210 9066 or +56 41 256 0288
Denmark: +45 32 71 31 57 or +45 89 88 37 88
New Zealand: +64 4 886 0026 or +64 9 884 6780
Georgia: +995 3224 73988 or +995 7067 77954
Portugal: +351 308 804 188 or +351 308 810 988
Israel: +972 3 978 6688 or +972 55 330 1762
South Africa: +27 87 551 7702
Bahrain: +973 1619 7601 or +973 1619 8488
Malaysia: +60 3 3099 2229 or +60 3 9212 1727
Spain: +34 84 368 5025 or +34 917 873 431
Croatia: +385 1300 0988 or +385 1777 6333
Singapore: +65 3158 7288 or +65 3165 1065
Switzerland: +41 31 528 09 88 or +41 43 210 70 42
Latvia: +371 6303 1808 or +371 6303 1888
Germany: +49 30 5679 5800 or +49 69 7104 9922
Norway: +47 2396 0588 or +47 7349 4877
United Kingdom: +44 131 460 1196 or +44 203 481 5237
Puerto Rico: +1 787 945 1488 or +1 787 966 7727
Ireland: +353 1 653 3895 or +353 6 163 9031
El Salvador: +503 2113 9088 or +503 2136 6444
Russian Federation: +7 495 283 9788 or +7 812 426 8988
Austria: +43 670 309 0165 or +43 72 011 5988
Bulgaria: +359 2 492 5688 or +359 3 257 1633
Webinar ID: 987 5874 2464
International numbers available: https://mit.zoom.us/u/abTjhMfAY
Or an H.323/SIP room system:
H.323:
162.255.37.11 (US West)
162.255.36.11 (US East)
115.114.131.7 (India Mumbai)
115.114.115.7 (India Hyderabad)
213.19.144.110 (EMEA)
103.122.166.55 (Australia)
209.9.211.110 (Hong Kong
China)
64.211.144.160 (Brazil)
69.174.57.160 (Canada)
207.226.132.110 (Japan)
Meeting ID: 987 5874 2464
SIP: 98758742464@zoomcrc.com